منابع مشابه
Proton Transfer in Ribozyme Catalysis
This chapter provides an overview of recent progress in understanding proton transfer in RNA enzymes. It was over 10 years ago that the previous book by the same editors was published. In that volume, there was no chapter on proton transfer. Indeed, it was unclear whether proton transfer made important contributions to RNA catalysis. Many things have changed in the last decade. Most importantly...
متن کاملProton transfer in imidazole-based molecular crystals.
Heterocycles' aggregates show rather good proton conductivity. In particular, condensed structures formed by imidazole rings that are held together by polymeric chains have attracted some interest as possible candidate materials for fuel cell membranes. However, the details of the proton diffusion process could not be resolved by means of experimental measurements because of the fast rearrangem...
متن کاملImidazole catalysis. II. Acyl transfer and the reactions of acetyl imidazole with water and oxygen anions.
Catalysis of p-nitrophenyl acetate hydrolysis by imidazole and its derivatives has been described in a number of investigations, of which the most extensive are those by Bruice and Schmir and by Bender and Turnquest (2-9). Imidaaole catalysis of the transfer of activated acyl groups from acyl phosphates to a number of acceptor molecules, which is a model for carboxylactivating enzymes and trans...
متن کاملSolvent-mediated proton transfer in catalysis by carbonic anhydrase.
Considerable attention has been focused on proton transfer through intervening water molecules in complex macromolecules of biological interest, such as bacteriorhodopsin, cytochrome c oxidase, and many others. Proton transfer in catalysis by carbonic anhydrase provides a useful model for the study of the properties of such proton translocations. High-resolution X-ray crystallography in combina...
متن کاملEnzymatic Catalysis of Proton Transfer and Decarboxylation Reactions.
Deprotonation of carbon and decarboxylation at enzyme active sites proceed through the same carbanion intermediates as for the uncatalyzed reactions in water. The mechanism for the enzymatic reactions can be studied at the same level of detail as for nonenzymatic reactions, using the mechanistic tools developed by physical organic chemists. Triosephosphate isomerase (TIM) catalyzed interconvers...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1970
ISSN: 0306-3283
DOI: 10.1042/bj1170050pa